Karyotyping Activity

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Name: ___________________________________ Date: _______________________ Period: ________
Karyotyping Activity
Objectives:
1. Identify pairs of homologous chromosomes by length, centromere position, and banding patterns.
2. Determine the sex of an individual from a karyotype.
3. Analyze and predict whether an individual will have a genetic disorder.
Materials:
Chromosome spread
Scissors
Karyotype analysis worksheet
Tape
Ruler
Background Information
Each of the cells in a human’s body arise from a single fertilized egg. This fertilized egg contains all of the
instructions for development. Half of the genetic material comes from the mother (packaged in the egg) and
half of the information comes from the father (delivered in the sperm cell).
The genetic information in the fertilized egg (embryo) is packaged in DNA located on chromosomes. By
performing an analysis of these chromosomes, one can diagnose several genetic disorders. This analysis is
called “karyotyping” and is accomplished by matching the homologous chromosomes.
Carefully observe the sample karyotype and list three ways that homologous chromosomes can be grouped
together:
1. ________________________________________________________________________________
2. ________________________________________________________________________________
3. ________________________________________________________________________________
What makes chromosomes “homologous” pairs?
Once again referring to the sample karyotype provided, what is different about the chromosomes in box 23?

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