Salivascan Saliva Alcohol Test - Cj Cooper And Associates printable pdf download

GLOSSARY OF SYMBOLS

Interpretation of Results

Amphetamine(AMP): Amphetamines (amphetamine,

SalivaScan

™

methamphetamine, and the structurally related “designer” drugs, e.g.,

Positive: The saliva Alcohol Test will produce a color change in the

catalog number

“ecstasy”) are sympathomimetic amines whose biological effects

presence of saliva alcohol. The color will range from light blue color at

include potent central nervous system (cns) stimulation, anorectic,

0.02% relative blood alcohol concentration to a dark blue color near

consult instructions for use

hyperthermic, and cardiovascular properties. They are usually taken

For Forensic Use

0.30% relative blood alcohol concentration. color pads are provided

orally, intravenously, or by smoking. Amphetamines are readily absorbed

within this range to allow an approximation of relative blood alcohol

Manufacturer

INTENDED USE

from the gastrointestinal tract and are then either deactivated by the liver.

concentration. The test may produce colors that appear to be between

The Drugcheck

salivascan

™

oral Fluid Drug Test is a rapid visual

Amphetamines increase the heart rate and blood pressure and suppress

adjacent color pads.

Temperature limitation

immunoassay for the qualitative, presumptive detection of drugs of

the appetite. some studies indicate that heavy abuse may result in

noTe: The saliva Alcohol Test is very sensitive to the presence of

abuse in human oral fluid specimens. The test system consists of one or

permanent damage to certain essential nerve structures in the brain.

Batch code

alcohol. A blue color that is lighter than the 0.02% color pad should be

two membrane strips mounted in a plastic cassette.

Benzodiazepine(BZO): Benzodiazepines are medications that are

interpreted as being positive to the presence of alcohol in saliva but less

Use by

This test detects combinations of the following drugs at the

frequently prescribed for the symptomatic treatment of anxiety and

than 0.02% relative blood alcohol.

concentrations listed below. specific combinations will vary according to

sleep disorders. They produce their effects via specific receptors

Do not reuse

negative: When the saliva Alcohol Test shows no color change this

the test in question:

involving a neurochemical called gamma aminobutyric acid (GABA).

should be interpreted as a negative result indicating that alcohol has not

Because they are safer and more effective, Benzodiazepines have

Test

Calibrator

Cut-off

Do not use if package is damaged

been detected.

replaced Barbiturates in the treatment of both anxiety and insomnia.

(ng/mL)

invalid: if the color pad has a blue color before applying saliva sample,

Benzodiazepines are also used as sedatives before some surgical and

sufficient for (quantity)

Amphetamine (AMP)

D-Amphetamine

do not use the test.

medical procedures, and for the treatment of seizure disorders and

Benzodiazepine (BZo)

oxazepam

alcohol withdrawal.

Authorized representative in the european community

noTe: A result where the outer edges of the color pad produces a slight

Buprenorphine (BUP)

Buprenorphine

cocaine (coc)

Benzoylecgonine

Benzoylecgonine/Cocaine(COC): Derived from leaves of the coca

color but the majority of the pad remains colorless the test should be

cotinine (coT)

cotinine

repeated to ensure complete saturation of the pad with saliva. The test

plant, cocaine is a potent central nervous system stimulant and a local

is not reusable.

eDDP (eDDP)

2-ethyliden-1,5-Dimethyl-

anesthetic. Among the psychological effects induced by using cocaine

3,3-Diphenylpyrrolidine

are euphoria, confidence and a sense of increased energy, accompanied

NOTE: The following instructions pertain only to devices that

Limitations

Ketamine (KeT)

Ketamine

by increased heart rate, dilation of the pupils, fever, tremors and

contain an alcohol test strip.

Marijuana (THc)

11-nor-D9-THc-9 cooH

1. Failure to wait 15 minutes after placing food, drink, or other materials

sweating. cocaine is excreted in saliva primarily as benzoylecgonine in a

Marijuana (THc)

(including smoking) in the mouth before running the test can produce

D9-THc

short period of time.

Saliva Alcohol Test

Methadone (MTD)

Methadone

erroneous results due to possible contamination of the saliva by

Buprenorphine(BUP): Buprenorphine is a potent analgesic often

Methamphetamine (MeT) D-Methamphetamine

interfering substances.

used in the treatment of opioid addiction. The drug is sold under the

opiates (oPi)

opiates

Intended Use

2. The saliva Alcohol Test is highly sensitive to the presence of alcohol.

trade names subutex

™

, Buprenex

™

,Temgesic

™

and suboxone

™

,which

oxycodone (oXY)

oxycodone

Alcohol vapors in the air are sometimes detected by the saliva Alcohol

contain Buprenorphine Hcl alone or in combination whith naloxone

The saliva Alcohol Test is a rapid, highly sensitive method to detect

Phencyclidine (PcP)

Phencyclidine

Test. Alcohol vapors are present in many institutions and homes. Alcohol

Hcl. Therapeutically, Buprenorphine is used as a substitution treatment

the presence of alcohol in saliva and provide an approximation of

Propoxyphene (PPX)

Propoxyphene

is a component in many household products such as disinfectant,

for opioid addicts.substitution treatment is a form of medical care

relative blood alcohol concentration. This test provides a preliminary

Barbiturate (BAr)

Barbiturate

deodorizers, perfumes, and glass cleaners. if the presence of alcohol

offered to opiate addicts(primarily heroin addicts)based on a similar or

screen only. A more specific alternate chemical method must be used

PRINCIPLE

vapors is suspected, the test should be performed in an area known to

identical substance to the drug normally used. in substitution therapy,

in order to obtain a confirmed analytical result. clinical consideration

The Drugcheck salivascan is an immunoassay based on the principle

be free of vapors.

Buprenorphine is as effective as Methadone but demonstrates a lower

and professional judgment should be applied to any test screen result,

of competitive binding. Drugs that may be present in the oral fluid

level of physical dependence.concentrations of free Buprenorphine and

particularly when preliminary positive screens are indicated.

3. ingestion or general use of over-the-counter medications and

specimen compete against their respective drug conjugate for binding

Norbuprenorphine in saliva may be less than 1 ng/ml after therapeutic

products containing alcohol can produce positive results.

Summary

sites on their specific antibody.

administration,but can range up to 20 ng/ml in abuse situations.

Performance Characteristics

The plasma half-life of Buprenorphine is 2-4 hours.While complete

Two-thirds of all adults drink alcohol.

The blood alcohol concentration

During testing, a portion of the oral fluid specimen migrates upward by

at which a person becomes impaired is variable dependent upon the

elimination of a single-dose of the drug can take as long as 6 days,

The detection limit on the saliva Alcohol Test is from 0.02% to 0.30%

capillary action. A drug, if present in the oral fluid specimen below its

the detection window for the parent drug in urine is thought to be

individual. each individual has specific parameters that affect the level

for approximate relative blood alcohol level. The cutoff level of the saliva

cut-off concentration, will not saturate the binding sites of its specific

approximately 3 days.

of impairment such as size, weight, eating habits and alcohol tolerance.

Alcohol Test can vary based on local regulations and laws. Test results

antibody. The antibody will then react with the drug-protein conjugate

inappropriate consumption of alcohol can be a contributing factor to

can be compared to reference levels with color chart on the foil package.

and a visible colored line will show up in the test line region (T) of the

Cotinine(COT): cotinine is the first-stage metabolite of nicotine, a toxic

many accidents, injuries, and medical conditions.

specific drug strip. The presence of drug above the cut-off concentration

alkaloid that produces stimulation of the autonomic ganglia and central

Assay Specificity

in the oral fluid specimen will saturate all the binding sites of the

nervous system when in humans. nicotine is a drug to which virtually

Principle

The saliva Alcohol Test will react with methyl, ethyl and allyl alcohols.

antibody. Therefore, the colored line will not form in the test line region.

every member of a tobacco-smoking society is exposed whether through

it is well established that the concentration of alcohol in saliva is

direct contact or second-hand inhalation. in addition to tobacco, nicotine

Interfering Substances

A drug-positive oral fluid specimen will not generate a colored line in

comparable to that of blood.

The saliva Alcohol Test consists of a

2,3

is also commercially available as the active ingredient in smoking

the specific test line region of the strip because of drug competition,

plastic strip with a reaction pad attached at the tip. on contact with

The following substances may interfere with the saliva Alcohol Test when

replacement therapies such as nicotine gum, transdermal patches and

while a drug-negative oral fluid specimen will generate a line in the test

solutions of alcohol, the reaction pad will rapidly turn colors depending

using samples other than saliva. The named substances do not normally

nasal sprays.

line region because of the absence of drug competition. To serve as a

on the concentration of alcohol present. The pad employs a solid-phase

appear in sufficient quantity in saliva to interfere with the test.

procedural control, a colored line will always appear at the control line

EDDP(EDDP): Methadone (MTD) is a synthetic analgesic drug

chemistry which uses a highly specific enzyme reaction.

A. Agents which enhance color development

region (c), indicating that proper volume of specimen has been added

that is originally used in the treatment of narcotic addicts. Among

Reagents

• Peroxidases • Strong oxidizers

and membrane wicking has occurred.

the psychological effects induced by using methadone are

analgesia,sedation and respiratory depression.overdose of methadone

• Tetramethylbenzidine • Alcohol Oxidase (EC 1.1.3.13)

B. Agents which inhibit color development

MATERIALS

may cause coma or even death. it is administered orally or intravenously

• Peroxidase (EC 1.11.1.7) • Other additives

• Reducing agents: Ascorbic acid, Tannic acid, Pyrogallol, Mercaptans

Materials Provided

and is metabolized in the liver. The kidneys are a major route of

and tosylates, oxalic acid, Uric Acid.

Precautions

• Individually packed screening devices and oral fluid collection swabs

methadone excretion. Methadone has a biological half-life of 16-50

hours. eDDP (2-ethyliden-1,5-Dimethyl-3,3-Diphenylpyrrolidine) is the

• Bilirubin • L-dopa • L-methyldopa • Methampyrone

The saliva Alcohol Test is a visually interpreted test where color

• Combined Test Procedure/Results Record sheet

most important metabolite of methadone. it is excreted into the bile

matching is used to provide an approximation of relative blood alcohol

Controls

• Package insert

and urine together with the other metabolite eMDP (2-ethyl-5-Methyl-

concentration. Test materials that have been exposed to saliva should be

The saliva Alcohol Test may be qualitatively verified by using a test

3,3-Diphenylpyrrolidine). eDDP is formed by n-demethylation and

treated as potentially infectious. Do not use the one step saliva Alcohol

solution prepared by adding 5 drops of 80 proof distilled spirits to 8 oz.

cyclization of methadone in the liver. The part of the unchanged excreted

Test after the expiration date marked on the foil package.

(1 cup) of water. This solution should produce a color reaction on the

methadone is variable and depends on the urine’s pH value,dose,and

Storage and Stability

pad. The color reaction with alcohol in saliva is somewhat slower and

the patient’s metabolism.Therefore, the detection of the metabolite

less intense than with alcohol in an aqueous solution.

eDDP instead of methadone itself is useful, because interferences of the

The saliva Alcohol Test is to be stored at 2-27°c (36-80°F) in its sealed

patient’s metabolism are avoided.

foil package. if storage temperatures exceed 27°c, the test performance

Bibliography

may degrade. if the product is refrigerated, the saliva Alcohol Test must

Ketamine (KET): Ketamine is a derivative of phencyclidine. it is used

1. Volpicellim, Joseph r., M.D., Ph.D.: Alcohol Dependence: Diagnosis, clinical Aspects and

be brought to room temperature prior to opening the pouch.

medically as a veterinary and human anaesthetic since 1970. About

Biopsychosocial Causes., Substance Abuse Library, University of Pennsylvania, 1997.

90 percent of the ketamine legally sold is intended for veterinary use.

Materials Provided

2. Jones, A.W.: Inter-and intra individual variations in the saliva/blood alcohol ratio during

it can be injected or snorted, but is sometimes sprinkled on tobacco

ethanol metabolism in man., clin. chem. 25, 1394-1398, 1979.

• 25 Individually foil pouched test devices

or marijuana and smoked. Ketamine is frequently used in combination

3. MaCall, L.E.L., Whiting, B., Moore, M.R. and Goldberg, A.: Correlation of ethanol

with other drugs, such as ecstasy, heroin or cocaine. Ketamine is also

• Package insert

concentrations in blood and saliva., clin.sci., 56, 283-286, 1979.

known as “special K” or “vitamin K.” certain doses of Ketamine can

Materials Required But Not Provided

cause dream-like states and hallucinations. in high dose, ketamine can

• Timer

cause delirium, amnesia, impaired motor function, high blood pressure,

depression, and potentially fatal respiratory problems. Ketamine is

Directions For Use

metabolized in the liver and excreted through the kidney.

Allow the pouched strip to equilibrate to room temperature (15-27°c)

Marijuana(THC): Tetrahydrocannabinol, the active ingredient in the

prior to testing.

marijuana plant (cannabis sativa), is detectable in saliva shortly after

1. Abstain from placing anything in the mouth for fifteen (15) minutes

use. The detection of the drug is thought to be primarily due to the direct

express Diagnostics int’l, inc.

cePartner4U

prior to beginning the test. This includes non-alcoholic drinks, tobacco

exposure of the drug to the mouth (oral and smoking administrations)

1550 industrial Drive

esdoornlaan 13

products, coffee, breath mints and food, etc.

and the subsequent sequestering of the drug in the buccal cavity3.

Blue earth, Mn 56013 UsA

3951 DB Maarn

Historical studies have shown a window of detection for THc in saliva

2. open the foil package and remove the device. observe the reactive

of up to 14 hours after drug use3. The Marijuana THc 12 assay yields a

The netherlands

pad on the end of the test strip. if the reaction pad has a blue color

Materials Required but Not provided

positive result when the THC-COOH concentration exceeds 12 ng/mL.

before applying saliva sample, do not use.

The Marijuana THc 50 assay yields a positive result when the D9-THc

• Timer

• Positive and negative controls

Dc202i-FUo March 2012

3. For specimen collection, follow Procedure instructions on page 2 of

concentration exceeds 50 ng/mL.

INTRODUCTION

this package insert.

Methadone(MTD): Methadone is a synthetic analgesic drug that

4. saturate the reactive pad with saliva. (it usually takes 6-8 seconds

The DrugCheck SalivaScan for AMP/BAR/BUP/BZO/COC/COT/EDDP/

is originally used in the treatment of narcotic addicts. Among the

KET/MET/MOR/ MTD/OXY/PCP/PPX/THC parent/THC and metabolites is

to be saturated.) start timer immediately after saliva application. read

psychological effects induced by using methadone are analgesia, sedation

a rapid,oral fluid screening test that can be performed without the use

result at two (2) minutes. compare the color of the reaction pad with the

and respiratory depression. overdose of methadone may cause coma or

color chart provided to determine the relative blood alcohol level.

of an instrument. The test utilizes monoclonal antibodies to selectively

even death. it is administered orally or intravenously and is metabolized in

detect elevated levels of specific drugs in human oral fluid.

the liver. The kidneys are a major route of methadone excretion.

Salivascan Saliva Alcohol Test - Cj Cooper And Associates

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