Liver Function And Bilirubin Metabolism - Unmc

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Study Questions: Liver Function and Bilirubin Metabolism
1.
The liver enzyme responsible for the conjugation of bilirubin is
bilirubin oxidase
glucuronyl transferase
(Crigler-Najjar, Gilberts syndromes: decreased enzyme levels
Dubin-Johnson disorder: disorder of bile excretion into bile)
2.
Explain why a normal newborn ordinarily will have an increased indirect bilirubin. Is
this normal?
3.
Why should a high bilirubin control (approx. 16-20 mg/dl) be included when a newborn's
th
bilirubin level is done? (refer Bishop, 5
ed, page 483)
4.
Hemolytic jaundice is classified as a prehepatic disorder. The characteristics of
hemolytic jaundice include (more than one answer):
a.
unconjugated serum bilirubin level greater than normal
b.
urinary bilirubin level greater than normal
c.
urinary urobilinogen level greater than normal
d.
fecal urobilinogen and urobilin levels less than normal
5.
A complete obstruction of the common bile duct would be characterized by which of the
following laboratory results (more than one answer):
a.
a negative urine urobilinogen
b.
a negative fecal urobilinogen and urobilin
c.
a positive urine bilirubin
d.
the excretion of a pale colored stool
6.
Kernicterus is the abnormal accumulation of free bilirubin in
_____
tissue.
7.
The Jendrassik-Grof method for bilirubin is a common method used with automated
systems. What effect will a hemolyzed test sample have on test results?
Lipemia interferes with any spectrophotometric method. What type of specimen is
preferred to minimize lipemic effects?
CLS 414 Clinical Chemistry Rotation I
2
Unit 2: Liver Function Study Question

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