Form 8729 - Authorization Is Granted To Dispense And Administer An Alternate Drug Product

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Form # 8729 (10/14)
AUTHORIZATION IS GRANTED TO DISPENSE AND ADMINISTER AN ALTERNATE DRUG PRODUCT ACCEPTABLE TO THE MEDICAL STAFF'S
PHARMACY COMMITTEE UNLESS THE DRUG PRODUCT IS SPECIFICALLY CIRCLED.
1.
Allergies / Sensitivities (include types of reactions)________________________________________________________
________________________________________________________________________________________________
2.
Height:__________________cm
Actual Weight:__________________kg
3.
INDICaTIoN
Hypogammaglobulinemia
Idiopathic Thrombocytopenic Purpura - ITP
Hereditary
Kawasaki Disease (Mucocutaneous Lymph Node Syndrome)
Nonfamilial
Common Variable Immunodeficiency - CVID
with predominant abnormalities of B-cell numbers & function
Other__________________________________________
with autoantibodies to B or T-cells
other common variable immunodeficiencies
unspecified
IVIG is dosed using Ideal Body Weight (IBW). Use the following formula to calculate IBW.
For children LESS than 152cm tall use actual body weight.
For children 152cm or taller
IBW (males) = 39 + 0.9 (H - 152), where H is height in centimeters and IBW is weight in kilograms
IBW (females) = 42.2 + 0.9 (H - 152), where H is height in centimeters and IBW is weight in kilograms
4.
LaBoRaToRY
IgG Level - Draw level prior to starting IVIG infusion (Recommended to evaluate level each year).
IgG Level with Subclasses - Draw level prior to starting IVIG infusion.
5.
PRETREaTMENT and MoNIToRING - Give the following pre-medications 30 minutes prior to the start of infusion.
None
Acetaminophen (15 mg/kg) _____________ mg PO (Maximum: 650 mg/dose)
Acetaminophen (15 mg/kg) _____________ mg PR (Maximum: 650 mg/dose)
Diphenhydramine (1.25 mg/kg) __________ mg PO (Maximum: 50 mg/dose)
Diphenhydramine (1.25 mg/kg) __________ mg IV (Maximum: 50 mg/dose)
Hydrocortisone (2.5 mg/kg) _____________ mg IV (Maximum: 100 mg/dose)
Nursing to assess hydration. Call prescribing physician if patient may be volume depleted prior to beginning infusion.
Obtain baseline vital signs (BP, pulse, respirations, temperature) pre-infusion, then Q15 minutes until maximum delivery rate is reached. Then every
hour times 2, then Q2 hours until completed and 15 -30 minutes after the completion of the infusion.
6.
DoSING of IVIG
IVIG (______ mg/kg) IV Frequency ____________
Total Dose: _____________ grams (Round to the nearest 5 gm +/- 5%. If rounding to
nearest 5 gm exceeds +/- 5% call provider for approval.)
Duration__________doses or ______weeks (Maximum duration of 1 year) - if not specified, the order will be considered as a one-time order and must be
rewritten. Refer to back page for specific infusion instructions.
7. aDMINISTRaTIoN and MoNIToRING
Gammagard (IVIG) Liquid
Begin infusion at 0.8 mg/kg/min for 30 minutes, if tolerated continue to increase every 30 minutes: 2 mg/kg/min, then 4 mg/kg/min, then
6 mg/kg/min, then to maximum rate of 8 mg/kg/min. (Max rate for pre-existing renal insufficiency or thrombotic risk is 3.3 mg/kg/min).
Use of an inline filter is optional.
Patients who have underlying renal disease or who are judged to be at risk of developing thromboembolic events should not be infused rapidly
with any IVIG product. Maximum infusion rate for pre-existing renal insufficiency or thrombotic risk is 3.3 mg/kg/min.
IVIG is to be administered with a separate infusion line with no other medications.
Patients who are on long term IVIG therapy may have physician orders with a more rapid titration rate to decrease total infusion time.
Monitoring
For common reactions (including fever, nausea, or vomiting)
- Temporarily stop or slow infusion rate to that previously tolerated by patient and treat symptoms as required
For chills or rigors decrease infusion rate to that previously tolerated by patient and notify physician
For serious reactions including hypotension, angioedema, bronchospasms, dyspnea, and anaphylaxis
- Stop infusion, notify physician, and treat symptoms as required.
- Begin IV of 0.9% Sodium Chloride to keep line open.
- Administer diphenhydramine 1.25 mg/kg IVP (max 50mg), hydrocortisone 2.5mg/kg IVP (max: 100mg), epinephrine 0.01mg/kg IM (max: 0.3mg)
The physician's full signature, date & time is to follow the order -
Patient ID Label
Abbreviations for names are not acceptable.
Signature
Date
Time
IVIG PEDIATRIC ORDERS

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