Draft Data Validation Plan Review Form Page 22
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29Draft Data Validation PRF-Tier II
Date: March 2, 2004
Page 22
Revision: 4.0
1.0
Tentatively Identified Compounds
When a library search is completed in which a unknown mass spectrum of a compound is compared to the mass spectra of
compounds contained in a computer library in an effort to identify the compound, the compounds identified in this manner
are referred to as tentatively identified compounds (TICs). Evaluation
TICs are compounds detected in samples that are not target compounds, internal standards, or surrogate standards. These
compounds may be of interest due to potential toxicity, or otherwise indicate a potential constituent of concern, or because
they may act as interferants in the analysis. Up to 30 peaks (those greater than 10% of peak areas or heights of nearest internal
standards) are subjected to mass spectral library searches for tentative identification. Evaluations of TICs are not commonly
included as part of a data submittal. An evaluation of TICs may arise when a ground water sample is analyzed for the
“Appendix IX” list.
1.1
W ere chromatograms provided and reviewed?
Action: If chromatograms were not provided, request data from the facility.
1.2
W ere the TICs qualitatively identified via an electronic library
search? W hich search engine was used:
NIST /EP A/N IH/ W iley M ass S pectral Library?
Action: Identify whether an electronic library search was employed and
what spectral library was searched.
1.3
Did the laboratory report the TICs as target compounds by any
other analytical method (e.g., with semi-volatile compound
analysis) ?
Action: If so, d o no t repo rt the com pou nd a s a T IC.
1.4
May any of the TICs be eliminated due to being a target analyte,
a system m onitoring compound, or an internal standard?
Action: If yes, rem ove the com pun d as a TIC and report it as a target
compound.
1.5
If target compounds have been identified, did the review verify
that quantitation had been made?
2.0
TICs in Blanks
2.1
W ere blank chromatograms examined to verify that TIC peaks
present in samples were not found in the blanks?
Action: If TICs were found in the blank, evaluate whether blank
contamination exists.
2.2
W ere all reported TICs sufficiently below 10x the level in the
blank?
Action: If not, report the compound as blank contamination and qua lify the
TIC as undetected.
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