Equivalent Dose Ratios For Opioids Chart

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EQUIVALENT DOSE RATIOS FOR OPIOIDS
Oral morphine : injectable morphine - 2 : 1
e.g. 20mg oral morphine : 10mg injectable morphine
Oral morphine : oral oxycodone - 2 : 1
e.g. 20mg oral morphine : 10mg oral oxycodone
Oral oxycodone : injectable oxycodone - 2 : 1
e.g. 20mg oral oxycodone : 10mg injectable oxycodone
Oral morphine : transdermal fentanyl (Durogesic)
Patch strength
Medication
Delivery rate (mcg/hour)
Oral morphine (mg/24hr)
Durogesic 12
Fentanyl
12.5
20 - 60
Durogesic 25
Fentanyl
25
60 - 134
Durogesic 50
Fentanyl
50
135 - 224
Durogesic 75
Fentanyl
75
225 - 314
Durogesic 100
Fentanyl
100
315 - 404
Oral morphine : transdermal buprenorphine (Norspan)
Patch strength
Medication
Delivery rate (mcg/hour)
Oral morphine (mg/24hr)
Norspan 5
Buprenorphine
5
9 - 13
Norspan 10
Buprenorphine
10
18 - 26
Norspan 20
Buprenorphine
20
36 - 53
Notes
If a drug is stronger, the dose required is smaller
For conversions from one alternate opioid to another, direct conversion ratios are
not so reliable. The preferred method is to convert drug A to oral morphine then
go from oral morphine to drug B – this may involve several steps. To check, use
the Guide to Equivalent Doses for Opioid Drugs chart.
For fentanyl and buprenorphine patches, remember that the strength refers to the
hourly absorption so:
 5mcg per hour = 24 x 5mcg in 24 hours = 120mcg in 24hrs
 25mcg per hour = 24 x 25mcg in 24 hours = 600mcg in 24hrs
 100mcg per hour = 24 x 100mcg in 24 hours = 2.4mg in 24hrs
(Hospice Waikato, November 2012 - adapted from St Christopher’s Hospice - Equivalent Dose Ratios For
Opioids, 2005, Waikato Hospital Palliative Care Guidelines, Calvary Health Care Bethlehem – Opioids Conversion
Guidelines, 2007)

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