Some Notes On The Rh And Hr Factors - Ncbi (Page 3 of 3) in pdf

CALIFORNIA MEDICINE

Vol.

67,

No. 1

of the fetus in utero. In such an instance, the infant

would be unaffected. (b) An Rh-positive fetus pro-

ducing specific sensitization of the mother. In such

an instance, the infant might be afflicted with hemo-

lytic disease of the newborn.

3. If antibodies occur only within the last

few

weeks of pregnancy they may indicate initial sensi-

tization in a mother not previously exposed to the

Rh factor. In such an instance the infant might show

mild symptoms of hemolytic disease of the newborn

or be

clinically normal.

In regard to the prediction of hemolytic disease

of the newborn

it may

be stated that occasionally

hemolytic disease of the newborn may occur

off-

spring of women who do not demonstrate any

laboratory evidence of Rh sensitization. This occurs

in roughly 10 per cent of the instances of the disease

and is due to the A-B-O and Hr sensitization and

other mechanisms. On the other hand, a clinically

normal Rh positive child

may be

born

to an

negative mother who shows abundant evidence of

current Rh sensitization.

REFERENCES

1. Cappell, D. F.: The Blood Group Rh, Brit. Med. Jour.,

2:601 and 641 (Oct. 26 and Nov. 2), 1946.

2. Davidsohn, I.: Rh Antibodies, Amer. J. Clin. Path.,

15:95-105 (March), 1945.

3. Diamond, L. K., and Denton, R. L.: Rh Agglutination

in Various Media with Particular Reference to the Value of

Albumin, J. Lab. and Clin. Med., 30:821-830 (Oct.), 1945.

4. Diamond, L. K., and Abelson, N. M.: The Detection

of Rh Sensitization: Evaluation of Tests for Rh

Antibodies,

J. Lab. and Clin. Med., 30:668-674 (Aug.), 1945.

5. Fisher, R. A., and Race, R. R.: Rh

Gene Frequencies

in Britain, Nature, 157, p. 48 (Jan. 12), 1946.

6. Hill, J. M., and Haberman, S.: Demonstration of Rh

Antibodies in the Newborn and Further Evidence of the

Pathogenesis of Erythroblastosis, Jour. Lab. and Clin. Med.,

31:1053-1066 (Oct.), 1946.

7. Howard, J., Lucia, S. P., Hunt, M. L., and Mclvor, B. C.:

The Clinical Significance of Rh Antibodies (Rh Agglutinins

and Blocking Antibodies)

the Sera of Rh-negative Moth-

ers: A Study of 176

Cases, Amer. Jour. Obst. & Gynec.,

53:569-595 (Apr.), 1947.

Wiener, A. S.:

A New Test

("Blbcking Test") for

Sensitization,

Proc. Soc. Exp. Biol. & Med., 56:173-176

(June),,

1944.

9. Wiener, A. S.: Conglutination Tests for Rh Sensitiza-

tion, Jour. Lab. & Clin. Med., 30:662-667 (Aug.), 1945.

10.

Wiener, A. S.: Recent Developments

the Knowledge

of the Rh-Hr Blood

Types: Tests

for Rh

Sensitization,

Am.

J. Clin. Path., 16:477-497,

1946.

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