Opioid Manager Template Page 2

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C
Maintenance & Monitoring
Maintenance & Monitoring Chart
Morphine Equivalence Table
D / M / Y D / M / Y
D / M / Y
D / M / Y
D / M / Y
D / M / Y
Opioid
Equivalent
Conversion
Date
Doses (mg)
to MEQ
Opioid prescribed
Morphine
30
1
Daily dose
Codeine
200
0.15
Daily morphine equivalent
Oxycodone
20
1.5
More than 200
Watchful Dose
Hydromorphone
6
5
> than 200
Less than 200
Meperidine
300
0.1
Goals achieved
Yes, No, Partially
Methadone & Tramadol
Dose Equivalents unreliable
Pain intensity
60 – 134 mg morphine = 25 mcg/h
Transdermal
Functional status
Improved, No Change, Worsened
135 – 179 mg = 37 mcg/h
fentanyl
Adverse effects
Nausea
180 – 224 mg = 50 mcg/h
225 – 269 mg = 62 mcg/h
Constipation
270 – 314 mg = 75 mcg/h
Drowsiness
0 = None
315 – 359 mg = 87 mcg/h
Dizziness/Vertigo
360 – 404 mg = 100 mcg/h
1 = Limits ADLs
2 = Prevents ADLs
Dry skin/Pruritis
Switching Opioids:
Vomiting
If previous opioid
Then, SUGGESTED
Other?
dose was:
new opioid dose is:
Complications?
(Reviewed: Y/N)
50% or less of previous opioid
High
Aberrant Behaviour
(Reviewed: Y/N)
(converted to morphine equivalent)
Urine Drug Screening (Y/N)
60-75% of the previous opioid
Moderate or low
(converted to morphine equivalent)
Other Medications
D
When is it time to Decrease the dose or Stop the Opioid completely?
Aberrant Drug Related Behaviour
(Modified by Passik,Kirsh et al 2002).
Indicator
Examples
How to Stop – the essentials
When to stop opioids
Examples and Considerations
*Altering the route of delivery
• Injecting, biting or crushing oral formulations
How do I stop?
The opioid should be
*Accessing opioids from
• Taking the drug from friends or relatives
tapered rather than abruptly discontinued.
other sources
• Purchasing the drug from the “street”
Pain Condition Resolved
Patient receives definitive treatment for condition. A trial of tapering is warranted
• Double-doctoring
to determine if the original pain condition has resolved.
How long will it take to stop the
• Multiple unauthorized dose escalations
Unsanctioned use
opioid?
Tapers can usually be completed
Risks Outweighs Benefits
Overdose risk has increased.
• Binge rather than scheduled use
between 2 weeks to 4 months.
Clear evidence of diversion.
• Recurrent prescription losses
Aberrant drug related behaviours have become apparent.
Drug seeking
• Aggressive complaining about the need for higher doses
When do I need to be more cautious
• Harassing staff for faxed scripts or fit-in appointments
Adverse Effects
when tapering? Pregnancy:
Adverse effects impairs functioning below baseline level.
• Nothing else “works”
Outweighs Benefits
Patient does not tolerate adverse effects.
Severe, acute opioid withdrawal has been
Repeated withdrawal symptoms
• Marked dysphoria, myalgias, GI symptoms, craving
associated with premature labour and
Medical complications have arisen (e.g. hypogonadism, sleep apnea,
spontaneous abortion.
Medical Complications
• Currently addicted to alcohol, cocaine, cannabis or other drugs
opioid induced hyperalgesia)
Accompanying conditions
• Underlying mood or anxiety disorders not responsive to treatment
How do I decrease the dose?
Opioid effectiveness = improved function or at least
• Deteriorating or poor social function
Opioid Not Effective
Decrease the dose by no more than 10% of
Social features
30% reduction in pain intensity
• Concern expressed by family members
the total daily dose every 1-2 weeks. Once
Pain and function remains unresponsive.
one-third of the original dose is reached,
• Sometimes acknowledges being addicted
Opioid being used to regulate mood rather than pain control.
Views on the opioid
• Strong resistance to tapering or switching opioids
decrease by 5% every 2-4 weeks. Avoid
Periodic dose tapering or cessation of therapy should be considered to confirm
medication
• May admit to mood-leveling effect
sedative-hypnotic drugs, especially
opioid therapy effectiveness.
• May acknowledge distressing withdrawal symptoms
benzodiazepines, during the taper.
= behaviours more indicative of addiction than the others.
*
National Opioid Use Guideline Group (NOUGG)
To access the Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-cancer Pain and to download the Opioid Manager visit

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