Human Karyotype Pedigree Analysis Page 2

Part 2: Abnormal Karyotype

Karyotypes c an b e u sed t o i dentify a n umber o f c hromosomal m utations. T ranslocation d efects,

inversion m utations, a ddition a nd d eletion m utations a re a ll c hromosome s tructure m utations.

nondisjunction a nd p olyploidy a re c hromosome n umber m utations.

Nondisjunction i s t he f ailure o f c hromosomes t o s eparate d uring a naphase o f c ell d ivision. T his

results i n m onosomy a nd t risomy c onditions.

7. What i s t he d ifference b etween m onosomy a nd t risomy?

8. How c ould n ondisjunction r esult i n a n i ndividual w ith D own’s S yndrome?

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