Public Employees' Chemical Right To Know Act Page 23
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31(b)
A chemical that has a median lethal dose of 200 milligrams or less
per kilogram of body weight when administered by continuous contact for 24 hours (or
less if death occurs within 24 hours) with the bare skin of albino rabbits weighing between
two and three kilograms each.
(c)
A chemical that has a median lethal concentration in air of 200
parts per million by volume or less of gas or vapor, or 2 milligrams per liter or less of mist,
fume, or dust, when administered by continuous inhalation for one hour (or less if death
occurs within one hour) to albino rats weighing between 200 and 300 grams each.
(4)
Irritant: A chemical, which is not corrosive, but which causes a reversible
inflammatory effect on living tissue by chemical action at the site of contact. A chemical is
a skin irritant if, when tested on the intact skin of albino rabbits by the methods of 16 CFR
1500.41 for four hours exposure or by other appropriate techniques, it results in an
empirical score of five or more. A chemical is an eye irritant, if so determined under the
procedure listed in 16 CFR 1500.42 or other appropriate techniques.
(5)
Sensitizer. A chemical that causes a substantial proportion of exposed
people or animals to develop an allergic reaction in normal tissue after repeated exposure
to the chemical.
(6)
Toxic. A chemical falling within any of the following categories:
(a)
A chemical that has a median lethal dose of more than 50
milligrams per kilogram but not more than 500 milligrams per kilogram of body weight
when administered orally to albino rats weighing between 200 and 300 grams each.
(b)
A chemical that has a median lethal dose of more than 200
milligrams per kilogram but not more than 1,000 milligrams per kilogram of body weight
when administered by continuous contact for 24 hours (or less if death occurs within 24
hours) with the bare skin of albino rabbits weighing between two and three kilograms
each.
(c)
A chemical that has a median lethal concentration in air of more
than 200 parts per million but not more than 2,000 parts per million by volume of gas or
vapor, or more than two milligrams per liter but not more than 20 milligrams per liter of
mist, fume, or dust, when administered by continuous inhalation for one hour (or less if
death occurs within one hour) to albino rats weighing between 200 and 300 grams each.
(7)
Target organ effects. The following is a target organ categorization of
effects which may occur, including examples of signs and symptoms and chemicals which
have been found to cause such effects. These examples are presented to illustrate the
range and diversity of effects and hazards found in the workplace, and the broad scope
employers must consider in this area, but are not intended to be all-inclusive.
(a)
Hepatotoxins: Chemicals which produce liver damage
Signs & Symptoms: Jaundice; liver enlargement
Chemicals: Carbon tetrachloride; nitrosamines
(b)
Nephrotoxins: Chemicals which produce kidney damage
Signs & Symptoms: Edema; proteinuria
Chemicals: Halogenated hydrocarbons; uranium
(c)
Neurotoxins: Chemicals which produce their primary toxic effects
on the
nervous system
Signs & Symptoms: Narcosis; behavioral changes; decrease in
motor
functions
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