University Of Michigan Nephrology Clinic Anemia Management Orders Page 3
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4Erythropoeitin Analog Dosing and Conversions
Single Use Dosages for EPO analogs
PROCRIT (units)
ARANESP (mcg)
2000
25
3000
40
4000
60
10,000
100
40,000
150
Darbepoetin (Aranesp) and Epoetin (Procrit) Dose Conversions
Weekly Epoetin
Weekly Darbepoetin
Every other week Darbepoetin
(units/week)
(mcg/week)
(mcg/every other week)
< 2,500
6.25
25 mcg monthly
2,500 to 4,999
12.5
25
5,000 to 10,999
25
40
11,000 to 17,999
40
80 or 100
18,000 to 33,999
60
100
34,000 to 89,999
100
200
⇐⇐
≥ 90,000
200
Stepwise Dose adjustments (to increase by ~25%, rounded to nearest whole dosing unit)
Epoetin (Procrit)
CURRENT DOSE (UNITS)
STEP INCREASE (≈ 25%⇑)
STEP DECREASE (≈ 25%⇓)
2,000 every 1week
3,000 every 1 week
2,000 every 2 weeks
3,000 every 1 week
4,000 every 1 week
2,000 every 1 week
4,000 every 1 week
3,000 twice weekly
3,000 every 1 week
3,000 twice weekly
10,000 every 1 week
4,000 every 1 week
10,000 every 1 week
13,000 every 1 week
8,000 every 1 week
10,000 twice weekly
14,000 twice weekly
14,000 every 1 week
13,000 every 1 week
10,000 twice weekly
10,000 every 1 week
14,000 every 1 week
20,000 every 1 week
10,000 every 1 week
14,000 twice weekly
40,000 every 1 week
10, 000 twice weekly
40,000 every 1 week
50,000 every 1 week
30,000 weekly
Darbepoetin (Aranesp)
CURRENT DOSE (MCG)
STEP INCREASE (≈ 25%⇑)
STEP DECREASE (≈ 25%⇓)
25 every 2 weeks
40 every 2 weeks
25 every 3 weeks
40 every 2 weeks
60 every 2 weeks
25 every 2 weeks
60 every 2 weeks
80 every 2 weeks
40 every 2 weeks
80 every 2 weeks
100 every 2 weeks
60 every 2 weeks
100 every 2 weeks
100 every 1 week
80 every 2 weeks
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