Medication Chart For Type 2 Diabetes (Page 2 of 4) in pdf

Medication Chart for Type 2 Diabetes

page 2 of 4

Dosing

Med Group Descriptor,

Action, Side Effects, Notes

Considerations

Dosage

Drug Class, Drug Name

Frequency/Day

Ranges

Glucagon-Like Peptide-1 (GLP-1)

10-20 mcg/day.

Action: Enhances glucose-dependent

Exenatide (BYETTA)

2 times/day.

For extended

insulin secretion.

Average A1c decrease 0.5-1%.

For extended release:

release:

Also available in extended release:

Side effects: Nausea, hypoglycemia,

Exenatide XR (BYDUREON)

1 time/week.

2 mg/week.

vomiting, diarrhea, feeling jittery,

dizziness, headache, dyspepsia.

Liraglutide (VICTOZA)

1 time/day.

0.6-1.8 mg/day.

Average A1c decrease 0.5-1%.

Alpha-Glucosidase Inhibitors (AGI)

Acarbose (PRECOSE)

Action: Delays absorption and

breakdown of carbohydrates from

3 times/day, with first bite of

intestines

75-300 mg/day.

Average A1c decrease 0.5-1%.

meal.

Miglitol (GLYSET)

Side effects: Gas, diarrhea, stomach

upset.

Fixed Combinations

Available in 2.5mg/250mg,

Glipizide and Metformin

Cautious use of metformin

2.5mg/500mg, and 5mg/500mg

(METAGLIP)

with renal impairment

strengths.

(Scr >1.5 md/dL in men;

Available in 1.25mg/250mg, 2.5

Scr >1.4 mg/dL in women or

Glyburide and Metformin

1–2 times/day, with meals.

mg/500mg, and 5mg/500mg

GFR <60).

(GLUCOVANCE)

strengths.

Pioglitazone and Metformin

See black box warning for

Available in 15mg/500mg and

(ACTOPLUS MET)

15mg/850mg strengths.

Actos above.

Cautious use of metformin

with renal impairment

See individual

Pioglitazone and Metformin

Available in 15mg/1000mg and

(Scr >1.5 md/dL in men;

products above.

1 time/day, with evening meal.

ER (ACTOPLUS MET XR)

30mg/1000mg strengths.

Scr >1.4 mg/dL in women or

GFR <60).

Pioglitazone and Glimepride

Available in 30mg/2mg and

See black box warning for

1 time/day, before first meal.

(DUETACT)

30mg/4mg strengths

Actos above.

Sitagliptin and Metformin

Available in 50mg/500mg and

Cautious use of metformin

2 times/day, taken with food.

50mg/1000 mg strengths.

(JANUMET)

with renal impairment

(Scr >1.5 md/dL in men;

Saxagliptin and Metformin

Available in 5mg/500mg, 5mg/1000

Scr >1.4 mg/dL in women or

1 time/day, taken with food.

(KOMBIGLYZE XR)

mg and 2.5mg/1000mg strengths.

GFR <60).

Insulins

Bolus Insulin: Rapid- or Short-Acting

Onset of Action

Peak Effect

Duration of Action

Lispro (Humalog), aspart (Novolog), glulisine (Apidra)

15 - 30 minutes

30 - 150 minutes

≤ 5 hours

Regular (Humulin R, Novolin R)

30 minutes

2.5 - 5 hours

4 - 12 hours

Basal Insulin: Intermediate- or Long-Acting

Onset of Action

Peak Effect

Duration of Action

NPH (Humulin N, Novolin N)

About 2 hours

4 - 12 hours

12 - 20 hours

Detemir (Levemir)

3 - 4 hours

3 - 9 hours

16 - 23 hours

Glargine (Lantus)

3 - 4 hours

No peak

≥ 24 hours

Insulin Mixes

Onset of Action

Peak Effect

Duration of Action

NPH/regular (Humulin 70/30, Novolin 70/30)

Lispro protamine/lispro (Humalog Mix 50/50, Humalog Mix 75/25)

See individual products above.

Aspart protamine/aspart (Novolog Mix 70/30)

See pages 3-4 for insulin titration algorithms >>

This medication chart is designed to assist clinicians in diabetes management. It is not intended to replace a clinician’s judgment or establish a protocol for all patients.

For national recommendations, references and additional copies of the guideline, go to or call (303) 446-7200. This medication chart was supported with funds from The Colorado Health Foundation.

Developed February 2012.

Medication Chart For Type 2 Diabetes Page 2

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