Approximate Pka Values Of Ionizable Groups Of Amino Acids Page 2
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2Hydropathy values
These numbers are taken from one of many scales that describe the hydrophobicity of the amino acids.
The more positive the value, the more hydrophobic the aa. (Likewise, the more negative the value, the
more hydrophilic the aa.) In other scales, the order of amino acids (from most to least hydrophobic)
may vary, but the general progression is similar.
(from J. Kyte & R. F. Doolittle. A simple method for displaying the hydropathic character of a protein.
J Mol Biol, 157, 105-132):
Isoleucine
4.50
Methionine
1.90
Tryptophan
-0.90
Glutamic acid -3.50
Valine
4.20
Alanine
1.80
Tyrosine
-1.30
Asparagine
-3.50
Leucine
3.80
Glycine
-0.40
Proline
-1.60
Glutamine
-3.50
Phenylalanine 2.80
Threonine
-0.70
Histidine
-3.20
Lysine
-3.90
Cysteine
2.50
Serine
-0.80
Aspartic acid -3.50
Arginine
-4.50
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