Protein Synthesis Page 4

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SICM Tuition
Biology AS
The Human Genome Project
-
A part of a DNA molecule which codes for a single polypeptide is called a
gene.
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In humans, it is estimated that there are about 140 000 genes
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The total set of genes is called the genome
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The genome represents the genetic code for a particular organism
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The human genome project was a project to find out the FULL base
sequence of the human genome
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There are about 3 billion bases in the human genome. The aim is to
identify each human gene
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This was completed in 2003
Ethical issues
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gene testing:
o can improve lives but has problems such as abortion issues
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possibility of cloning
SYLLABUS CHECKLIST
Unit 2.1.2 – Nucleic Acids
Candidates should be able to:
(a)
state that deoxyribonucleic acid (DNA) is a polynucleotide, usually double
stranded, made up of nucleotides containing the bases adenine (A), thymine (T),
cytosine (C) and guanine (G);
(b)
state that ribonucleic acid (RNA) is a polynucleotide, usually single stranded,
made up of nucleotides containing the bases adenine (A), uracil (U), cytosine
(C) and guanine (G);
(c)
describe, with the aid of diagrams, how hydrogen bonding between
complementary base pairs (A to T, G to C) on two antiparallel DNA
polynucleotides leads to the formation of a DNA molecule, and how the twisting
of DNA produces its ‘double-helix’ shape (HSW1);
(d)
outline, with the aid of diagrams, how DNA replicates semi-conservatively, with
reference to the role of DNA polymerase;
(e)
state that a gene is a sequence of DNA nucleotides that codes for a polypeptide
(HSW3);
(f)
outline the roles of DNA and RNA in living organisms (the concept of protein
synthesis must be considered in outline only).
Page 8

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