Blood Test Clinical Significance Chart Page 11
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28CREATININE
released into the blood.
CREATININE CLEARANCE (CON’T)
The amount produced is
relatively stable in a given
person. The creatinine
level in the serum is
therefore determined by the
rate it is being removed,
which is roughly a measure
of kidney function. If
kidney function falls (say a
kidney is removed to donate
to a relative), the creatinine
level will rise. Normal is
about 1 for an average
adult. Infants that have
little muscle will have
lower normal levels (0.2).
Muscle bound weight lifters
may have a higher normal
creatinine. Serum
creatinine only reflects
renal function in a steady
state. After removing a
kidney, if the donor’s blood
is checked right away the
serum creatinine will still
be 1. In the next day the
creatinine will rise to a new
steady state (usually about
1.8). If both kidneys were
removed (say for cancer)
the creatinine would
continue to rise daily until
dialysis is begun. How fast
it rises depends on
creatinine production,
which is again related to
how much muscle one has.
Creatinine clearance is
technically the amount of
blood that is “cleared” of
creatinine per time period.
It is usually expressed in
mL per minute. Normal is
120 mL/min for an adult. It
is roughly, inversely related
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