Blood Test Clinical Significance Chart Page 5
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28ALBUMIN (CON’T)
cancer chemotherapy,
Cushing’s disease, familial
hypoproteinemia).
ALKALINE PHOSPHATASE
INCREASED serum
49-142 IU/L
alkaline phosphatase is seen
in states of increased
osteoblastic activity
(hyperparathyroidism,
osteomalacia, primary and
metastatic neoplasms),
hepatobiliary diseases
characterized by some
degree of intra- or
extrahepatic cholestasis,
and in sepsis, chronic
inflammatory bowel
disease, and thyrotoxicosis.
Isoenzymes determination
may help determine the
organ/tissue responsible for
an alkaline phosphatase
elevation.
DECREASED serum
alkaline phosphatase may
not be clinically significant.
However, decreased serum
levels have been observed
in hypothyroidism, scurvy,
kwashiorkor,
achrondroplastic dwarfism,
deposition of radioactive
materials in bone, and in the
rare genetic condition
hypophosphatasia.
There are probably more
variations in the way in
which alkaline phosphatase
is assayed than any other
enzyme. Therefore, the
reporting units vary from
place to place. The
reference range for the
assaying laboraotory must
be carefully studied when
interpreting any individual
result.
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