Pharmacology Drug Chart Page 8
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18Pharmacology Drug Chart Page 8
α1 Antagonist
Postural Hypotension α1
Vasodilation
β1 Antagonist
↓ BP
Dizziness α1
β2 Partial Agonist
↓ HR
Labetalol
Treatment of Hypertension - Especially useful for
patients with Asthma and Diabetics due to the
β2 partial agonist effect
Drugs Affecting Neurotransmitter Release
Drug Name
Receptor
Therapeutic Uses
Adverse Effects
2+
ACTION
Causes the ultimate depletion of Norepinephrine
Mg
/ ATP
2+
in the adrenergic neuron
Dependent
Blocks the Mg
/ ATP Dependent transporter
Sympathetic function is greatly impaired
Transporter
from transporting Norepinephrine, Dopamine
May cause Bradycardia
and Serotonin from the cytoplasm into the
Reserpine
storage vesicles
THERAPEUTIC USES
Treatment of Hypertension
Mechanism 1 - Displaces Norepinephrine from
Postural Hypotension
storage vesicles
Male sexual function interference
Mechanism 2 - Blocks the release of stored
Hypertensive Crisis in patients with
Norepinephrine
Pheochromocytoma due to a supersensitivity to
Guanethidine
Treatment of Hypertension (Rarely Used)
Norepinephrine
↓ BP
↓ HR
+
+
Inhibits reuptake 1 of Norepinephrine from the
Causes the accumulation of Norepinephrine in
Na
/ K
ATPase
synaptic cleft by blocking Na/K ATPase
the synaptic space
Cocaine
Causes an enhancement of Sympathetic activity
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